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Nicotinamide deoxyriboside derivatives, such as nicotinamide 2-deoxyriboside and 5-methylnicotinamide 2-deoxyriboside, act as mechanism-based small molecule inhibitors of CD38 by forming stable covalent intermediates 132

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In the future, this mechanism might also extend to novel treatments of other neuroinflammatory and neurodegenerative conditions. The study is published in the journal Cell Reports .

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