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Danot O
Additionally, some individuals taking Mounjaro may have pre-existing conditions that independently increase their risk of B12 deficiency, such as previous bariatric surgery or concurrent metformin use (the MHRA has highlighted that metformin can reduce vitamin B12 levels)
Mechanistic proof should combine pathway inhibition, co-localization with Rab5, Rab7, and lysosome markers, and detection of intact peptide on the basolateral side by liquid chromatographymass spectrometry, with a functional bioactivity readout when endosomal escape is claimed [130,131]
PMID 11470726
