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These studies suggest that some GST family members function as auxiliary factors in metabolite transport processes rather than as primary membrane transporters

Proteinuria has further been hypothesized to reflect systemic endothelial dysfunction, oxidative stress, and insulin resistance, which may indirectly contribute to PD pathophysiology [151]

This doesn't mean the compound "doesn't work"it means the evidence base is predominantly preclinical

Athira Pharma's fosgonimeton (ATH-1017) targets the same HGF/c-Met program but is structurally distinct (sources conflict on whether it is a prodrug of Dihexa or a separate molecule)