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[14] demonstrated that NNMT is a positive modulator in hepatocyte gluconeogenesis but the roles of NNMT in glycogen metabolism in the liver and the mechanisms by which NNMT affects insulin sensitivity have not yet been reported

It is possible that their function is also influenced locally by estrogens or other steroid receptors in the BBB

Salman KE, Altunay IK, Kucukunal NA, Cerman AA
