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Our goal here is to unpack the science, look at the potential pathways, and provide a clear, authoritative perspective for researchers navigating this complex topic
Methylene Blue (1% in DPBS
Voitcitctkii, A
13a, Supplementary Table 9), suggesting that the distinct rotamer orientation of H296 ECL2 in Cagri-bound CTR (to accommodate the Glu linker) and/or the observed more open ECL3 conformation induced by the lipidated peptide may facilitate or stabilize an active CTR conformation (Supplementary Fig
