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[thelancet.com] Significant reductions in HbA1c and body weight across multiple dosing regimens

Second, the cycling recommendation, 8-12 weeks on followed by a 4-week off period, is based on the general principle applied to peptide therapies to prevent receptor desensitization and to allow assessment of lasting effects, rather than on direct MOTS-c cycling data

Rats underwent renal ischemia for 45 min