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NRF2 stimulates the mitochondrial biogenesis program through activation of nuclear respiratory factor-1 (NRF-1), which transcribes the key mitochondrial biogenesis factors transcription factor A, mitochondrial (TFAM) and transcription factor B2, mitochondrial (TFBM2) [115]

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Adrenal Stress and Cortisol Dysregulation: Chronic stress and adrenal fatigue can suppress thyroid hormone production and worsen symptoms

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These NPs also facilitate the ligand-polymer conjugation which further enhances their functioning [236]

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