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Moreover, multiple in vitro (64,65) and in vivo (66,67) studies suggest that ergothioneine activates the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), which triggers the cellular antioxidant defence system

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doi: 10.1199:tab.0123 [DOI] [PMC free article] [PubMed] [Google Scholar] Kawashima C.G., Berkowitz O., Hell R., Noji M., Saito K

The human bodys ability to circulate energy, its metabolism, and its antioxidant capacity weakens as it ages, resulting in impaired energy circulation, increased free radicals, and accelerated apoptosis in the cochlea, which diminishes hearing