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They are particularly useful for individuals who have difficulty absorbing B12 from food, such as those with certain digestive issues, older adults, vegans, and vegetarians

Elevated methylmalonic acid above 0.4 micromoles per liter confirms functional B12 deficiency even when serum levels appear adequate

While traditionally regarded as a vitamin B clearance enzyme, over the past decade NNMTs role has expanded dramaticallyto include reprogramming onecarbon metabolism, impacting NAD levels, DNA/histone methylation, and even tumor progression and angiogenesis

For instance, vitamin B12 supports the nervous system, while vitamin D affects mood functions in the brain