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TPD52 activates CMA physiologically by enhancing the transfer of CMA protein substrates in prostate cancer cells through complex formation with HSPA8

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The most striking result is the lower mtROS at 120 h, indicating that the initial increase in mtROS and subsequent increase in antioxidant enzyme activity ultimately lowered net mtROS production to a level lower than controls, which is the proposed explanation for the more than twofold increase in lifespan