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For most of the carcinogenic NAs, the established mechanisms of action involve metabolic activation primarily via cytochrome 450 enzymes (CYPs), and mainly through -hydroxylation, generating highly reactive, electrophilic intermediates, which can ultimately form covalent DNA adducts

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The patients provided written informed consent for the use of their resected tissues for research purposes

10.1161/CIRCULATIONAHA.106.679597 Park TS, Hu Y, Noh HL, Drosatos K, Okajima K, Buchanan J, Tuinei J, Homma S, Jiang XC, Abel ED, Goldberg IJ: Ceramide is a cardiotoxin in lipotoxic cardiomyopathy