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The OHP-induced cytotoxicity in primary Schwann cells and the myelin basic protein expression decreasing indicated that the platinum derivatives also induced Schwann cells mitochondrial dysfunction in vitro [90]

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Neuropathological investigations in the substantia nigra pars compacta of Parkinsons disease patients demonstrate that deficient PGC-1 expression compromises mitochondrial biogenesis and disrupts the coordinated transcriptional activation of antioxidant stress-responsive gene networks, thereby precipitating dopaminergic neuronal degeneration (Piccinin et al., 2021)

In addition, it is reported that silencing iron response element binding protein 2 can increase the content of iron in cells through transferrin receptor, and eventually induce ferroptosis (Dixon et al., 2012