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In human embryonic stem cells (hESCs), the conserved lncRNA-FAST binds to the WD40 domain of the E3 ubiquitin ligase -TrCP, inhibiting the ubiquitination of -catenin by -TrCP, resulting in the accumulation of -catenin in the nucleus

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[14] Pernicious anemia due to autoimmune problems occurs in about one per 1000 people in the US