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Description
Initially considered the sole enzyme capable of degrading GSH, GGT hydrolyzes the -glutamyl bond of extracellular reduced and oxidized GSH (22)
The latter includes compounds like piperlongumine, which selectively activates oxidative stress responses in cancer cells by interacting with proteins that regulate oxidative stress, such as CBR1, GSTP1, and their complexes, thereby inducing cancer cell death under high ROS levels 119
Age-related changes in AMPK activation: role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways
Postgrad Med J 1999;75:451452 1999 75(NA):451 - 452 Z
