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91 Oral administrated NAM is converted into NA in the small intestine and colon by nicotinamidase PncA of gut microbiota

Gregory LC, Shah P, Sanner JRF, Arancibia M, Hurst J, Jones WD, Spoudeas H, Le Quesne Stabej P, Williams HJ, Ocaka LA, Loureiro C, Martinez-Aguayo A, Dattani MT
Endocrinology 137 (4), 13951401

The effects may vary with each individual, depending on the specific peptide therapy being administered, the health issue being addressed, and its severity