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The protein binds to LAMP-2A, a lysosomal membrane protein, and is then translocated into the lysosome for degradation

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The cataplerotic enzyme, mitochondrial glutamic-oxaloacetic transaminase (GOT2), was increased in PSAT1 KO mice fed a HF-SAAR diet compared to both their WT littermates and KO mice fed HF-CTRL (Fig