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10.3389/fmicb.2021.719877 Front

Important Note on the Evidence Base Important note on the evidence base: The preclinical AOD-9604 literature in obese mouse and Zucker rat models is consistent and reproducible

When glutathione (0.03 mg/mL) was added and bound to the silver nanoparticles, the silver nanoparticles underwent agglomeration resulting in an increase in potential due to the decrease in the spacing of silver nanoparticles caused by the adsorption of glutathione on the surface of silver nanoparticles

This greatly reduces the amount of NADPH that is available for glutathione reductase, an enzyme critical for antioxidant defense