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However, as opposed to adult humans, where IGF-2 levels are substantial, systemic IGF-2 levels are undetectable in adult rodents

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(Green R, et al., Nature Reviews Disease Primers, 2017 PubMed: 28660890 ) Because B12 is water-soluble, excess amounts that the body cannot use are excreted in urine rather than stored

The same is true for our relatively new coronavirus vaccines. The Centers for Disease Control and Prevention has recommended a booster dose to enhance the efficacy of the Pfizer and Moderna vaccines, starting as soon as September 20 for individuals at least eight months after their second vaccine dose (it has not been recommended yet for the Johnson & Johnson vaccine)
