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Xie X, Liu H, Wang Y, Zhou Y, Yu H, Li G, Ruan Z, Li F, Wang X, Zhang J (2016) Nicotinamide N-methyltransferase enhances resistance to 5-fluorouracil in colorectal cancer cells through inhibition of the ASK1-p38 MAPK pathway

This restores the function of the methylmalonyl-CoA mutase enzyme, allowing the seamless conversion of methylmalonyl-CoA into succinyl-CoA

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Given the ability of tesofensine to modulate the activity of the LH, our preclinical findings agree with the proposal that tesofensine could be a useful treatment for patients with hypothalamic obesity, a rare feeding disorder, as recently demonstrated [38]