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Description
In apoptosis, -sitosterol upregulates pro-apoptotic factors such as p53 and Bax, while downregulating anti-apoptotic proteins such as Bcl-2, leading to an increase in mitochondrial outer membrane permeability and the activation of key apoptotic enzyme cascades such as caspase-9 and 3, which induces programmed cell death (83)
Glutamine increases expressions of these three proteins either in the absence or in the presence of PMA
Elevated levels of GST activity have been associated with resistance to all the major classes of insecticides (Ranson and Hemingway, 2005)
Cell 172 , 409422 e421 (2018)
