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Description
The ARF Study Group

Dynamic interactions between structural domains form a cascade regulatory network: Single-molecule FRET experiments confirmed that GCN5L triggers N-terminal to C-terminal conformational coupling upon binding coenzyme A, expanding the substrate-binding pocket diameter in the catalytic domain from 1.8 to 3.5, making it much easier for large metabolic enzymes (for example, the 150 kDa branched-chain -ketoacid dehydrogenase) to bind

Blood 110(11):708a, 2007

The study aims to investigate the impact of glutathione or its enriched yeast extract, which is recognized for its antioxidant characteristics, on alcohol metabolism and alleviating hangovers in a rat model exposed to binge drinking