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Yes, the cortisol gut microbiome connection matters because gut bacteria help regulate estrogen metabolism, cortisol balance, inflammation, and emotional stability, all of which change during menopause

Oxidative stress and glyoxalase I activity mediate dicarbonyl toxicity in MCF-7 mamma carcinoma cells and a tamoxifen resistant derivative

10.1038/s41392-021-00687-0 Signal Transduct Target Ther

doi:10.1146/annurev.genet.37.040103.095211
