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Abbreviations A: amyloid beta AD: Alzheimers disease AKT: protein kinase B ApoE: apolipoprotein E CAR: carnitines CE: cholesteryl esters CLU: clusterin CTD: C-terminal domain DCX: doublecortin ERK1/2: extracellular signal-regulated kinase GFAP: glial fibrillary acidic protein GD: di-sialo-glycosphingolipid GM: mono-sialo-glycosphingolipids HD: hinge domain HDX-MS: hydrogen-deuterium exchange mass spectrometry HNRNPAB: heterogenous nuclear ribonucleoprotein A/B IBA1: ionized calcium-binding adapter molecule 1 LPC-O: alkyl ether-linked lysophosphatidylcholines MAP2: microtubule-associated protein 2 MD: molecular dynamics NCAM1: neural cell adhesion molecule 1 NEFM: neurofilament medium polypeptide NMR: nuclear magnetic resonance NPC2: NPC intracellular cholesterol transporter 2 NTD: N-terminal domain MAP2: microtubule-associated protein 2 PAX6: paired box protein Pax-6 PCA: principal component analysis PC-O: alkyl ether-linked phosphatidylcholines PE-O: alkyl ether-linked phosphatidylethanolamines PPIA: alkyl ether-linked phosphatidylethanolamines S100b: S100 calcium-binding protein B SPA: 3-sulfopropanoic acid SRM: selected reaction monitoring TEM: transmission electron microscopy TUJ: tubulin beta-3 chain