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This cytokine signals in an autocrine/paracrine manner through the TNF receptor to activate the mitogen-activated protein kinases p44/42 and JNK that, in turn, downregulate perilipin mRNA and protein expression (104, 105)

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Sanofi (Europe and USA) designed SAR442257, a trispecific antibody where CD38 confers target specificity and CD3 and CD28 provide dual activation signals to optimize T lymphocyte effector functions and to ensure sustained proliferation