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The substrates for these reactions are both endogenous (intrinsic) and exogenous (xenobiotics), being mainly electrophiles, Michael acceptors, epoxides, electron-withdrawing structures and carbonyls, which are able to react through nucleophilic additions with GSH

PMID: 64 HuangLZhangYLiuYLiangZChenJWangBet al

Duncan AJ, Heales SJ

While other atypical Parkinsons syndromes (APS), such as PSP, multisystemic atrophy (MSA), and corticobasal ganglion syndrome (CBS), are characterized by a marked increase in NfL level of CSF due to myelin axonal involvement, this pathological process is not typical in the early stages of PD (von Widekind et al., 2020)