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Oxidative damage to lung mitochondrial DNA is a key contributor to the development of chemical lung injury

Prog Neuro-Psychopharmacol Biol Psychiatry 84:93101 Conn PJ, Pin J-P (1997) Pharmacology and functions of metabotropic glutamate receptors

Among break-bond prodrugs, AVA6000 (Figure 11) is a promising antineoplastic consisting of two moieties: a doxorubicin molecule linked to an FAP (fibroblast-activated protein ) binding moiety

a ligand having a Kd of at least about of 10 -7 M, at least about 10 -8 M, at least about 10 -9 M, at least about 10 -10 M, or can have a Kd of at least about 10 -11 M or 10 -12 M or greater