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In shuttle-saturated cells, reduced flux of pyruvate through the pyruvate dehydrogenase complex and the TCA cycle means less citrate is generated and exported from mitochondria
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Encyclopedia of Life Sciences (pp
Importantly, CHAC2 did not localize to the mitochondria irrespective of extracellular cystine availability, further suggesting divergent roles for these proteins in mediating intracellular GSH catabolism
