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The major location, within the brain, for norepinephrine synthesis is the locus coeruleus of the brainstem

doi: 10.1111/jog.15569 17 KitanoYHashimotoSMatsumotoHYamochiTYamanakaMNakaokaYet al

G., et al

CARDIOVASCULAR DRUGS IMPROVING ENDOTHELIAL FUNCTION Experimental and clinical studies have shown that numerous currently used or investigational drugs can improve endothelial function, although they have different structure and mechanisms of actions
