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There is no established safety data for the combination in any population, so the honest position is that contraindication data does not exist at the combination level

For broader context on aging biology and metabolic decline research, the NIH National Institute on Aging provides authoritative resources on the metabolic changes and epigenetic mechanisms that underlie age-associated obesity and sarcopenia

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Generally, only small, lipid-soluble molecules, certain gases, and some medications explicitly designed for this purpose can make it through