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ascorbate glutathione peroxidases Antioxidant Deficiencies in Hospitalized Dogs and Cats [State of the Art Lecture] - WSAVA2008 Glutathione
Description
In parallel, the hyperoxidizing ER environment oxidizes the regulatory disulfide bonds in ERO1, rendering it inactive and limiting disulfide-bond formation
![ascorbate glutathione peroxidases Antioxidant Deficiencies in Hospitalized Dogs and Cats [State of the Art Lecture] - WSAVA2008 Glutathione](https://bioone.org/ContentImages/Journals/arbo.j/2011/9/tab.0142/graphic/WebImages/f06_01.jpg)
The basic formula Concentration (mg/mL) = Total peptide (mg) Water volume (mL) For a 70mg vial with 3mL water: 70 3 = 23.33 mg/mL Volume to draw (mL) = Desired dose (mg) Concentration (mg/mL) For 2.33mg dose at 23.33 mg/mL: 2.33 23.33 = 0.10mL = 10 units on an insulin syringe Common vial sizes and calculations 42mg vial with 1.8mL water: Concentration: 23.33 mg/mL Standard dose (2.33mg): 10 units Conservative dose (1.165mg): 5 units Vial provides approximately 18 doses at standard protocol 70mg vial with 3mL water: Concentration: 23.33 mg/mL Standard dose (2.33mg): 10 units Conservative dose (1.165mg): 5 units Vial provides approximately 30 doses at standard protocol 70mg vial with 2mL water (higher concentration): Concentration: 35 mg/mL Standard dose (2.33mg): 6.7 units (round to 7) Conservative dose (1.165mg): 3.3 units (round to 3) Smaller volumes make precise measurement more difficult The SeekPeptides peptide calculator automates these calculations for any vial size and desired dose
![ascorbate glutathione peroxidases Antioxidant Deficiencies in Hospitalized Dogs and Cats [State of the Art Lecture] - WSAVA2008 Glutathione](https://media.springernature.com/lw685/springer-static/image/chp%3A10.1007%2F978-90-481-9404-9_1/MediaObjects/978-90-481-9404-9_1_Fig1_HTML.gif)
Furthermore, the HCV genotypes also affect glutathione levels in a different way
Energetic cost of brain functional connectivity
![ascorbate glutathione peroxidases Antioxidant Deficiencies in Hospitalized Dogs and Cats [State of the Art Lecture] - WSAVA2008 Glutathione](https://www.researchgate.net/publication/250008522/figure/fig1/AS:671518044463112@1537113786749/Reduction-of-hydrogen-peroxide-H-2-O-2-by-the-ascorbate-glutathione-cycle-DHA.png)