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It promotes the release of dopamine by stimulating the terminals of nigrostriatal dopaminergic neurons and reduces neuronal reuptake of dopamine, thereby increasing dopamine levels and exerting anti-parkinsonian effects [127]

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It protects important parts like mitochondria, proteins, lipids, and DNA

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Discovery of potent and selective rhodanine type IKKbeta inhibitors by hit-to-lead strategy

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Its core anthraquinone derivative, rhein, can activate the PPAR-CPT1A axis, upregulate sirtuin 1 (SIRT1), block the binding of STAT3 to the Twist1 promoter, promote the expression of CPT1A, and improve lipid metabolism [129, 130]

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