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Like vitamin B6, folate seems to improve cognitive function by lowering homocysteine levels, and a folate deficiency can induce fatigue and neurological issues, too.8 A 2021 review suggests that supplemental folate can improve cognitive decline in Alzheimers patients, but more research is necessary to confirm its usefulness.9 And a more recent 2023 meta-analysis on the effect of vitamin B and folate supplements on cognition in older adults found that, while they reduced homocysteine levels (as previous studies showed), the supplements failed to provide significant benefits over placebo in either slowing down or preventing cognitive decline.41 Ultimately, there isnt clear evidence that taking folate improves cognitive function in people who arent deficient