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In patients with AD, reduced activity of various TCA cycle enzymes, including isocitrate dehydrogenase, -ketoglutarate dehydrogenase, and pyruvate dehydrogenase, has been observed [130]
A 30-month, randomized, placebo-controlled trial of coenzyme Q 10 (600 mg/day), remacemide, or both in 347 patients with early Huntington's disease found that neither coenzyme Q 10 nor remacemide significantly altered the decline in total functional capacity, although coenzyme Q 10 supplementation (with or without remacemide) resulted in a nonsignificant trend toward a slower decline (73)
In fact, palatable foods are now known to share the same reward pathways as non-psychostimulant drugs of abuse [54]
Menghoum N, Oriot P, Hermans MP
