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A 2024 study in MASH patients and mouse models further confirmed that L-carnitine supplementation suppresses inflammatory gene expression ( Tnf, Il6, Il1b ) and downregulates pro-fibrotic genes ( Acta2, Col1a2, Tgfb1, Pdgfrb, Pdgf-b, Pdgf-c ), reducing -smooth muscle actin (-SMA) and platelet-derived growth factor receptor beta (PDGFR) protein levels (73)

Researchers at the Laboratory of Pharmaceutical Pharmacology (LIOS), in collaboration with Prof

Support for Healthy Aging and Metabolic Function : Carnitine levels naturally decline with age, which can impact mitochondrial function and metabolic health