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CONFLICT OF INTEREST The author confirms that this article content has no conflicts of interest

Daratumumab earned approval for monotherapy due to its efficacy, safety profile and durable responses demonstrated in the phase 1/2 GEN501 and the phase 2 SIRIUS clinical trials on heavily pretreated RRMM patients [71, 72]

However, to date there is no in vivo evidence that therapeutic anti-CD38 mAb exert their effects via inhibition of the CD38 NADase activity

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