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KD decreases the expression of pro-inflammatory proteins, such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase, which modulate the activity of cytokines IL-1, IL-2, IL-4, IL-6 and TNF- [38, 56]

Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones

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