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For drugs that are highly susceptible to first-pass metabolism, such as nitroglycerin, lidocaine, and propranolol, only a small fraction of the oral dose may reach the systemic circulation unchanged
Tran, Q
Biochem Biophys Res Commun 513, 2227
12, 13 In focal nodular hyperplasia, there is expansion of the -catenin-activated centrizonal region, which leads to overexpression in a characteristic geographic map-like pattern
