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A decrease in NAD + levels directly affects the metabolism of the bodys three major energy substances: sugar, fat, and protein, inducing MetS ( + levels across various mouse tissues, including adipose (Yoshino et al., 2011), skeletal muscle (Trammell et al., 2016), and hypothalamus (Sasaki et al., 2014), concomitant with the development of obesity

Li JH, Chen W, Zhu XJ, Lin YJ, Qiu LQ, Cai CX, Wang YH, Xiong Q, Chen F, Chen LH (2017) Associations of nicotinamide N -methyltransferase gene single nucleotide polymorphisms with sport performance and relative maximal gen uptake