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Frontiers in Pharmacology, 12 , 627533

We found that biotinylated sv6D and svC1 were poor substrates when assayed immediately after dissolving commercial lyophilized TGM2 in water containing 1 mM EDTA, pH 7.5, and 10 mM dithiothreitol (Figure 5a), but surprisingly, when the solution of TGM2 was stored over several days at 5 C in this medium, the enzyme lost over half of the activity with svL4 but gained the ability to use sv6D and, to a lesser extent, svC1 as substrates (Figure 5b)

Most of these compounds still lack robust clinical data proving their safety and long-term efficacy, says Dr

For users experiencing dose-dependent reactions, microdosing tirzepatide offers a gentler escalation approach