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[19] The enzymes that use B 12 as a built-in cofactor are methylmalonyl-CoA mutase (PDB 4REQ [43] ) and methionine synthase (PDB 1Q8J)

7 MTHFR and B12 deficiency People with MTHFR mutations may experience impaired B12 utilization, even if B12 levels appear normal

Neither is universally superior
