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For example, loss of Purkinje cells leads to anterograde trans-synaptic degeneration of cerebellar nuclei and retrograde trans-synaptic degeneration of cerebellar granule cells
In the chronic toxicity experiment, L-NAME caused severe tissue damage (myocardial and hepatic cell necrosis, necrosis of the lymphoid cells in the spleen) while L-arginine provoked predominantly congestion, edema and hemorrhages in all organs
These results suggest that low glutamine in the tumour microenvironment, similar to hypoxia, may drive cancer progression and augment resistance to treatment via epigenetic regulation
