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Glycolysis restriction limited the development of MDSCs by inhibiting tumor expression of granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage colony-stimulating factor (GM-CSF), therefore enhanced T cell immunity, reduced tumor growth and metastasis, and prolonged survival in two TNBC mouse models (285)
If these kinases are not balanced by phosphatases, enzymes that reverse phosphorylation, phosphorylation can predominate and lead to further accentuation of the original signal
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doi: 10.1002/jcp.27950
