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Description
In a Phase 1/1b trial, oral HDAC inhibitor Vorinostat (400 mg/day) combined with intravenous PD-1 inhibitor pembrolizumab (200 mg every 3 weeks) was administered to 33 patients, with good tolerability and no dose-limiting toxicity
[DOI] [PubMed] [Google Scholar] 60.Di Domenico F., Tramutola A., Butterfield D
2016;11:e0151492
A new mild symptom after a dose step is normal
