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B12 injections for weight loss capture the attention of the modern world because they combine valid scientific evidence with increasing popularity despite the abundant diet fads and so-called miracle supplements all the time filling social media feeds

Three RCTs met inclusion criteria The trials randomized 153 participants (74 participants to oral vitamin B12 and 79 participants to IM vitamin B 12 )

Importantly, persistently high serum B12 in the absence of supplementation should prompt GP assessment, as it may indicate underlying disease processes

We first examined the percentage of cells that fell within each of the 25 initial pseudotime bins by time point and age, and then used expression frequency of myogenic marker genes to inform myogenic cell-state annotations (Extended Data Fig