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Mice with RBC-specific deletion of eNOS show no change in resting coronary blood flow but exhibit elevated systemic blood pressure, indicating that RBC-derived NO contributes to maintaining vascular tone ( Hemoglobin, the most abundant protein in RBCs, engages in dynamic interactions with NO, forming a range of redox-related derivatives, including methemoglobin (MetHb) and HbNO
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[DOI] [PMC free article] [PubMed] [Google Scholar] 376.Inglis A., Parnell A.C., Subramani N., Doohan F.M
