most abundant glutathione transferase in liver alpha 1 2 3 Frontiers Hepatocyte glutathione S-transferase mu 2
Description
In vivo studies have shown that intravenously administered NAC reaches high concentrations in organs such as the lungs (320 M), kidneys (250 M), heart (170 M), and liver (100 M), with peak concentrations in human red blood cells reaching 200 M
Excessive alcohol metabolism in the liver produces ROS that can cross the blood-brain barrier, contributing to behavioral impairments associated with hangovers (Choi et al ., 2023
10.3389/fnagi.2017.00068 222 PimentelL
Describe the role of NADPH in detoxifying reactive oxygen species, and explain which cell types depend the most on the pentose phosphate pathway
