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doi: 10.1002/jcp.22266
The peptide Herdegradin, which downregulates EGFR, stimulates mitophagy through the mTORC2/Akt pathway, effectively inhibiting the growth of EGFR-positive cancers, such as PCa, ultimately inducing the death of PCa cells (Katreddy et al., 2018)
J Alzheimers Dis 65(4):12251236 Moore EM et al (2013) Increased risk of cognitive impairment in patients with diabetes is associated with metformin
In summary, CPP-CAND is a FOXO4-p53 interaction inhibitor that is anticipated to offer cost-effectiveness, high selectivity, and safety compared to previously developed peptide interaction inhibitors
