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Radiation-induced oxidative stress leads to the accumulation of inflammatory cells to secret cytokines facilitating the occurrence of RILI [133]

The three major metabolisms are not only independent of each other but are also related to each other through the TCA cycle

Common symptoms of low glutathione include: Chronic Fatigue Persistently feeling tired despite getting plenty of rest can be a sign of oxidative stress due to low glutathione

Oxidative stress is counteracted by a number of genes regulated by the nuclear transcription factor erythroid-derived 2-like 2 (NRF2), encoded by the NFE2L2 gene, which initiates antioxidant responses and detoxifies xenobiotics (Figure 7B)