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[DOI] [PMC free article] [PubMed] [Google Scholar] West M.B., Wickham S., Parks E.E., Sherry D.M., Hanigan M.H
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Consistently, a complementary strategy showed that in aged mice, where IGF-I levels are decreased, cardiac overexpression of IGF-I significantly improved cardiomyocyte contractile function[283], attenuating oxidative stress-mediated protein damage, normalizing Ca 2+ homeostasis, reversing age-related alterations in the expression of pro-apoptotic proteins, and decreasing the apoptosis rate[284]
Table 2 Summary of MSCs success in clinical trials
