glutathione is a key antioxidant discovered to play role in proper protein folding The antioxidant glutathione - ScienceDirect
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In melanoma models, the PERK inhibitor GSK2656157 combined with an mRNA vaccine promotes M1 macrophage polarization and enhances CD8(+) T cell infiltration, significantly suppressing tumor growth and metastasis [97]

This concept opens up exciting possibilities for new therapeutic strategies targeting metabolic pathways to enhance cognitive functions, especially in aging and neurodegenerative diseases (Lalo et al., 2021)

The malignant cells and normal cells were distinguished via the inferCNV algorithm on the basis of copy number variations (CNVs) (Fig
